Current perspective on auto-antibodies in type 1 diabetes

Anti-Interferon Auto-Antibodies in Autoimmune Polyendocrinopathy Syndrome Type 1

A utoimmunity is a common mechanism underlying many common human diseases. Although the mechanisms are not well understood, autoimmunity is thought to arise from a failure in self-tolerance, resulting in a sustained immunological attack by specifi c antibody, T cells, or both, directed against antigens within the target tissues or organs [1]. Many autoimmune disorders appear to have a genetic b...

Genetic Markers, Serological Auto Antibodies and Prediction of Type 1 Diabetes

Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications: Current Status and Future Perspective

1 Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5 2Division of Cardiology, Department of Medicine, Henry Ford Heart and Vascular Institute, 2799 West Grand Boulevard, Detroit, MI 48202-2689, USA 3Department of Pharmacology, Center for Integrative Medicine, Center for Molecular Medicine (CIMMBA), University of Florence, V...

Circulating antibodies to nephrin in patients with type 1 diabetes.

BACKGROUND Patients with type 1 diabetes typically develop autoantibodies to antigens of the pancreatic islet cells including insulin, glutamic acid decarboxylase and the protein tyrosine phosphatase-related islet antigen 2 protein. Nephrin is a protein shared by the kidney glomeruli, pancreatic beta-cells and islet microendothelia. Since circulating antibodies to nephrin have been shown to cau...

Type 1 Diabetes- Associated Antibodies during Pregnancy and in Infancy

There is evidence that the process leading to type 1 diabetes may start in early infancy or even in utero, with a prodrome of variable duration preceding clinical manifestation. The purpose of the present work was to learn more about the occurrence and significance of humoral beta-cell autoimmunity during pregnancy and in infancy, to search for possible signs of prenatal or early postnatal indu...